Company Overview:
BrilliantStrings Therapeutics is a pioneering biotechnology startup headquartered at JLabs @LabCentral in Cambridge, MA. We specialize in advancing orthopedic wound healing through direct-protein therapy. Our mission is to develop a comprehensive wound care platform that hyper-accelerates the healing of collagen-based tissues. As an early-stage startup, we are actively seeking visionary individuals to join us as the leaders of our scientific team. All research endeavors will adhere to rigorous FDA requirements, emphasizing the need for meticulous documentation to ensure regulatory compliance.
Position Overview:
As Senior Scientist, you will play a pivotal role in advancing our therapeutic development program. The ideal candidate will be a key contributor to our orthopedic wound healing technology by utilizing their expertise in cell culture, adherent bioreactors, and engineering of mammalian and human cells (e.g., fibroblasts). Bio-orthogonal labeling of the produced proteins will be an important aspect of the work.
Key Responsibilities:
- Engineer mammalian and human cells to optimize large protein upregulation.
- Ensure the stability of cell lines during the upregulation process, implementing measures to maintain the integrity and functionality of engineered cells.
- Develop and implement methodologies for quantifying production rates of therapeutic proteins, providing essential insights into the efficiency and productivity of cell culture processes.
- Employ analytical tools and techniques to assess and enhance overall production performance within the therapeutic development program.
- Lead the strategic scaling of cell culture processes, identifying opportunities for increased efficiency and scalability.
- Innovate and refine protocols for bio-orthogonal labeling of synthesized proteins.
- Collaborate with cross-functional teams to implement scalable solutions, ensuring seamless integration into the broader orthopedic wound healing platform.
Qualifications:
- Ph.D. in a relevant scientific discipline (Cell Biology, Molecular Biology, Bioengineering, Biomedical Engineering, or related field).
- Proven experience and proficiency in cell engineering to promote protein production (e.g. CRISPRa), establishing cell lines, assessing and optimizing protein expression.
- Demonstrated familiarity with different cell culture bioreactors and ability to scale cell culture processes for increased efficiency and productivity.
To Apply:
Please contact BrilliantStrings at Apply
Company Overview:
BrilliantStrings Therapeutics is a pioneering biotechnology startup headquartered at JLabs @LabCentral in Cambridge, MA. We specialize in advancing orthopedic wound healing through direct-protein therapy. Our mission is to develop a comprehensive wound care platform that hyper-accelerates the healing of collagen-based tissues. As an early-stage startup, we are actively seeking visionary individuals to join us as the leaders of our scientific team. All research endeavors will adhere to rigorous FDA requirements, emphasizing the need for meticulous documentation to ensure regulatory compliance.
Position Overview:
As Senior Scientist, you will play a pivotal role in advancing our therapeutic development program. Key responsibilities will involve formulating our therapeutic for optimal delivery and integration into damaged tissues at various stages of healing. Formulations will be tested both in vitro and in animal studies to assess the benefits of different compositions. Additionally, your role will extend to integrating sterilization procedures seamlessly into the product development.
Key Responsibilities:
- Lead the development and optimization of therapeutic formulations to enhance tissue integration.
- Plan and execute comprehensive in vitro experiments to assess the efficacy and safety of formulated therapeutics.
- Conduct and oversee animal studies to evaluate the benefits of different therapeutic compositions, providing valuable insights for clinical applications.
- Integrate sterilization procedures into the product development process, ensuring safety and compliance.
- Evaluate and select appropriate sterilization methods, considering their impact on therapeutic integrity, and collaborate with quality assurance teams on validation processes.
Qualifications:
- Ph.D. in a relevant scientific discipline (Biomaterials, Biochemistry, Bioengineering, Biomedical Engineering, or related field).
- Relevant publications in biomaterials, drug delivery, or a closely related discipline.
- Hands-on experience in formulating and developing biomaterial or therapeutic products, preferably in biotechnology or pharmaceutical settings.
- Proven success in designing and executing in vitro and in vivo studies.
- Knowledge of international regulatory requirements for therapeutic development is a plus.
To Apply:
Please contact BrilliantStrings at Apply
Company Overview:
BrilliantStrings Therapeutics is a pioneering biotechnology startup headquartered at JLabs @LabCentral in Cambridge, MA. We specialize in advancing orthopedic wound healing through direct-protein therapy. Our mission is to develop a comprehensive wound care platform that hyper-accelerates the healing of collagen-based tissues. As an early-stage startup, we are actively seeking visionary individuals to join us as the leaders of our scientific team. All research endeavors will adhere to rigorous FDA requirements, emphasizing the need for meticulous documentation to ensure regulatory compliance.
Position Overview:
As Senior Scientist, you will play a pivotal role in advancing our therapeutic development program. Key responsibilities will involve formulating our therapeutic for optimal delivery and integration into damaged tissues at various stages of healing. Formulations will be tested both in vitro and in animal studies to assess the benefits of different compositions. Additionally, your role will extend to integrating sterilization procedures seamlessly into the product development.
Key Responsibilities:
- Establish and optimize protocols for efficient protein extraction from both cell culture and tissue.
- Continuously refine and enhance extraction methodologies to ensure maximum yield and purity.
- Design and implement purification processes to isolate individual proteins from complex biological samples. Evaluate and implement cutting-edge techniques to enhance product quality.
- Conduct rigorous characterization and qualification assessments of extracted proteins.
- Implement quality control measures to ensure the consistency and purity of the final product.
- Lead exploratory scientific studies using extracted biologics to advance therapeutic development.
- Contribute to the design and execution of experiments aimed at expanding the understanding of protein-based therapeutic applications.
- Collaborate with interdisciplinary teams to integrate protein extraction findings into the overall therapeutic development strategy.
Qualifications:
- Ph.D. in a relevant scientific discipline (Biochemistry, Molecular Biology, Analytical Chemistry, Cell Biology, or related field).
- Hands-on experience in ECM protein extraction and purification. Proven track record of successful characterization of proteins. Familiarity with the hydroxyproline assay is a plus.
- Experience with analytical techniques such as mass spectrometry, HPLC, SDS PAGE, Western Blot, and ELISA.
To Apply:
Please contact BrilliantStrings at Apply
